circRNA basic information
circBase ID: -
Name: hsa_circ_AKT3
Synonym: circAKT3
Host Gene: AKT3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005381
MONDO name: bone disorder
Disease details: osteogenic differentiation
Disease DO ID:
 0080001
Disease MeSH ID:
 D001847
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

dental pulp tissue
Cell lines:

hDPSCs; HEK 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CX43
Associated microRNA: miR-206
Biological function: promotes osteogenic differentiation and mineralization of hDPSCs
Molecular mechanism: ceRNA sponge mechanism: circAKT3 binds miR-206 to relieve miR-206-mediated suppression of CX43
Biological pathway or process:

ceRNA regulation (promotes); osteogenesis (promotes); proliferation (not specified)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Sanger Sequencing; Transfection; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry)
Clinical significance:

-
Description:

circAKT3 is up-regulated during osteogenic differentiation of hDPSCs and promotes osteogenesis/mineralization. Mechanistically, it directly sponges miR-206, thereby relieving miR-206-mediated repression of CX43.
Confidence score:

0.7369
Other information
Title:

circAKT3 positively regulates osteogenic differentiation of human dental pulp stromal cells via miR-206/CX43 axis.

Journal: Stem cell research & therapy
Published: 2020
PubMed ID: 33298186
Study type:

combined biological and clinical study
Data availability: supplementary material available at 10.1186/s13287-020-02058-y
Code availability: -