| Expression pattern: |
UP |
| Associated gene: |
Sirt1, Ago2 |
| Associated microRNA: |
miR-138 |
| Biological function: |
Promotes spinal metastasis, proliferation, migration/invasion and EMT, and inhibits apoptosis in lung adenocarcinoma cells. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-138 to upregulate Sirt1, thereby promoting EMT and spinal metastasis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
May serve as a potential biomarker and therapeutic target for SM of lung adenocarcinoma. |
| Description: |
hsa_circ_0006571 (from SATB2) is up-regulated in spinal metastasis tissues of lung adenocarcinoma and mainly localizes to the cytoplasm. It promotes proliferation, migration/invasion, and EMT while inhibiting apoptosis by sponging miR-138 to increase Sirt1, forming a hsa_circ_0006571/miR-138/Sirt1 regulatory axis that contributes to spinal metastasis in vivo. |
| Confidence score: |
0.7452 |