| Expression pattern: |
UP |
| Associated gene: |
IGF1 |
| Associated microRNA: |
miR-4500 |
| Biological function: |
promotes breast cancer cell proliferation, migration and invasion; promotes tumor growth in vivo |
| Molecular mechanism: |
acts as a miRNA sponge (ceRNA) for miR-4500 to regulate IGF1 expression |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circPLK1 might be a promising prognostic biomarker and therapeutic target for BC |
| Description: |
circPLK1 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration and invasion, at least partly by sponging miR-4500 to increase IGF1 expression, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7591 |