circRNA basic information
circBase ID: hsa_circ_0007331
Name: hsa_circ_ACAP2
Synonym: circRNA-ACAP2
Host Gene: ACAP2
Genomic location(hg19): chr3:195101737-195112876:-
Genomic location(hg38): chr3:195381008-195392147:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021063
MONDO name: malignant colon neoplasm
Disease details: colon cancer
Disease DO ID:
 219
Disease MeSH ID:
 -
Disease NCIt ID:
 C9242
Disease ICD11 ID:
 1265576634
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

colon cancer tissue; distant normal mucous tissues
Cell lines:

SW480; HCT-116; HT-29; FIHC; 293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: Tiam1
Associated microRNA: miR-21-5p
Biological function: promotes proliferation, clonogenicity, migration, invasion and tumor growth; inhibits the suppressive effect of miR-21-5p on Tiam1
Molecular mechanism: ceRNA / miRNA sponge; circRNA-ACAP2 binds hsa-miR-21-5p to relieve inhibition of Tiam1 translation
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; Western Blot; Transwell Assay; Colony Formation Assay
Clinical significance:

The ceRNA network and pathway might be novel clinical markers and therapeutic targets for patients with colon cancer.
Description:

circRNA-ACAP2 is up-regulated in colon cancer and promotes SW480 cell proliferation, migration, invasion, clonogenicity, and in vivo tumor growth. Mechanistically, it acts as a miRNA sponge for hsa-miR-21-5p, thereby relieving repression of Tiam1 in a ceRNA axis.
Confidence score:

0.5925
Other information
Title:

The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Published: 2018
PubMed ID: 30212824
Study type:

combined biological and clinical study
Data availability: -
Code availability: -