| Expression pattern: |
UP |
| Associated gene: |
TRPS1, YAP1 |
| Associated microRNA: |
miR-129-5p |
| Biological function: |
Promotes osteosarcoma cell proliferation and cisplatin (DDP) drug resistance; supports tumor growth in xenografts. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-129-5p, thereby relieving repression on TRPS1 and YAP1 and affecting YAP1 phosphorylation status. |
| Biological pathway or process: |
proliferation (promotes); drug resistance (promotes); Hippo/YAP (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circTADA2A is up-regulated in osteosarcoma cell lines and promotes proliferation and cisplatin (DDP) resistance. Mechanistically, it sponges miR-129-5p to increase TRPS1 and YAP1 expression and modulate YAP1 phosphorylation, and its knockdown suppresses xenograft tumor growth and improves DDP sensitivity. |
| Confidence score: |
0.6216 |