| Expression pattern: |
UP |
| Associated gene: |
ZBED1 |
| Associated microRNA: |
hsa-miR-4326 |
| Biological function: |
May act as an oncogene in CRC; associated with distant metastasis and differentiation grade; potential prognostic biomarker. |
| Molecular mechanism: |
Constructed a ceRNA network in which hsa_circ_0004831 potentially regulates hsa-miR-4326 and downstream target mRNAs; co-expressed mRNAs linked to EMT, WNT and p53 signaling pathways (via GSEA). |
| Biological pathway or process: |
EMT (other); Wnt/beta-catenin (other); p53 signaling (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of hsa_circ_0004831 was linked with poorer prognosis; may be a blood-based prognostic biomarker for CRC. |
| Description: |
hsa_circ_0004831 is up-regulated in CRC serum/blood extracellular vesicles and its high expression is associated with poorer overall survival, suggesting it as a blood-based prognostic biomarker. The study proposes a ceRNA network in which hsa_circ_0004831 may regulate hsa-miR-4326 and downstream mRNAs, with co-expressed genes enriched in EMT, WNT and p53-related pathways. |
| Confidence score: |
0.5534 |