| Expression pattern: |
UP |
| Associated gene: |
ATAD2 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration, and invasion of liver cancer cells |
| Molecular mechanism: |
The specific molecular mechanism remains to be elucidated; hsa_circ_0085465 is derived from the ATAD2 gene and promotes malignant phenotypes in liver cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Transwell Assay |
| Clinical significance: |
hsa_circ_0085465 could be a valuable biomarker for the diagnosis and prognosis of liver cancer and a potential therapeutic biomarker. |
| Description: |
hsa_circ_0085465 is up-regulated in liver cancer serum, tissues, and liver cancer cell lines. The study functionally showed that overexpression of hsa_circ_0085465 promotes proliferation, migration, and invasion of 97 L liver cancer cells, suggesting relevance to liver cancer progression and biomarker potential. |
| Confidence score: |
0.6949 |