| Expression pattern: |
DN |
| Associated gene: |
FRMD6, Ago2, PCNA, Bcl-2, Bax, Ki67 |
| Associated microRNA: |
miR-93-5p |
| Biological function: |
Circ_VPRBP inhibits cervical cancer cell proliferation, migration and invasion, promotes apoptosis, and inhibits tumor growth in vivo. |
| Molecular mechanism: |
Circ_VPRBP functions as a ceRNA/miRNA sponge for miR-93-5p to upregulate FRMD6 expression, thereby suppressing cervical cancer progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Circ_VPRBP may be a potential biomarker and therapeutic target for cervical cancer. |
| Description: |
Circ_VPRBP is down-regulated in cervical cancer tissues and cells. Its overexpression suppresses malignant phenotypes, including proliferation, migration, invasion, and in vivo tumor growth, while promoting apoptosis. Mechanistically, circ_VPRBP sponges miR-93-5p to increase FRMD6 expression, forming a circ_VPRBP/miR-93-5p/FRMD6 tumor-suppressive axis. |
| Confidence score: |
0.8325 |