circRNA basic information
circBase ID: hsa_circ_0046264
Name: hsa_circ_P4HB
Synonym: -
Host Gene: P4HB
Genomic location(hg19): chr17:79813017-79817263:-
Genomic location(hg38): chr17:81855141-81859387:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary osteosarcoma tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: STC2, RASGRP2
Associated microRNA: hsa-miR-940, hsa-miR-223
Biological function: Might be a tumor inhibitor in osteosarcoma.
Molecular mechanism: ceRNA mechanism (predicted circRNA-miRNA-mRNA network)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa_circ_0046264 as down-regulated in osteosarcoma tissues and placed it into a predicted circRNA-miRNA-mRNA subnetwork involving hsa-miR-940/hsa-miR-223 and STC2/RASGRP2, suggesting a potential ceRNA role without experimental validation.
Confidence score:

0.1768
Other information
Title:

Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 34079579
Study type:

bioinformatics study
Data availability: GSE140256; GSE28423; GSE99671; https://www.ncbi.nlm.nih.gov/geo/; https://portal.gdc.cancer.gov/
Code availability: -