| Expression pattern: |
UP |
| Associated gene: |
STAT3 |
| Associated microRNA: |
miR-337-3p |
| Biological function: |
promotes hepatocellular carcinoma cell growth and invasion |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-337-3p to upregulate STAT3 (ceRNA mechanism) |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
High levels of hsa_circ_0006916 in hepatocellular carcinoma patients were associated with advanced TNM stage and lymph node metastasis |
| Description: |
hsa_circ_0006916 is up-regulated in hepatocellular carcinoma tissues and cell lines and promotes proliferation and invasion. Mechanistically, it localizes to the cytoplasm and functions as a miR-337-3p sponge to increase STAT3 expression, forming a hsa_circ_0006916/miR-337-3p/STAT3 axis linked to aggressive clinical features. |
| Confidence score: |
0.7477 |