| Expression pattern: |
UP |
| Associated gene: |
E‐cadherin (E‐cad), linear SPECC1 mRNA |
| Associated microRNA: |
- |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, and invasion; promotes tumor growth in vivo. |
| Molecular mechanism: |
Increased circ-0745 inhibits E-cadherin expression; knockdown elevates E-cadherin, suppressing migration and invasion. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Higher hsa_circ_0000745 expression is associated with poorly differentiated tumors and positive vascular/lymphatic invasion, suggesting worse prognosis and potential prognostic/therapeutic marker. |
| Description: |
hsa_circ_0000745 (circ-0745), derived from SPECC1, is up-regulated in cervical cancer/SCC tissues and promotes proliferation, migration, invasion and tumor growth. Mechanistically, circ-0745 represses E-cadherin, and its knockdown increases E-cadherin and reduces malignant phenotypes. Higher expression associates with poor differentiation and vascular/lymphatic invasion, suggesting prognostic relevance. |
| Confidence score: |
0.5802 |