| Expression pattern: |
UP |
| Associated gene: |
CAB39, GLS, QKI, AGO2 |
| Associated microRNA: |
miR-1265 |
| Biological function: |
promotes proliferation, migration, invasion, xenograft tumor growth and lung metastasis; promotes glutamine metabolism reprogramming |
| Molecular mechanism: |
ceRNA sponging miR-1265 to upregulate CAB39 and activate ERK signaling/EMT; regulates GLS expression to enhance glutamine metabolism; QKI promotes circGSK3B biogenesis |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ERK (promotes); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; In Vivo Animal Model; H&E Staining; Western Blot; IF (Immunofluorescence) |
| Clinical significance: |
circGSK3B expression level significantly correlated with HCC tumor size and vascular invasion; may serve as a promising diagnostic and prognostic marker in HCC |
| Description: |
circGSK3B (hsa_circ_0003763), derived from GSK3B, is up-regulated in HCC tissues and cell lines and promotes proliferation, migration, invasion and in vivo tumor growth/metastasis. Mechanistically, it sponges miR-1265 to upregulate CAB39 and activate downstream ERK/EMT, and it also enhances glutamine metabolism by increasing GLS expression; QKI promotes its biogenesis. |
| Confidence score: |
0.8546 |