| Expression pattern: |
UP |
| Associated gene: |
ABCB1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration, invasion and cisplatin resistance; inhibits apoptosis (knockdown promotes apoptosis). |
| Molecular mechanism: |
Enhances cisplatin resistance by promoting ABCB1 expression; ABCB1 overexpression rescues the effect of circRNA_103615 silencing. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circRNA_103615 expression levels in NSCLC patients were associated with a higher survival rate; increased expression was significantly associated with increased tumor size, advanced TNM stage and the presence of metastases. |
| Description: |
circRNA_103615 is upregulated in NSCLC tissues and cell lines. Its knockdown suppresses proliferation, migration, invasion and cisplatin resistance while promoting apoptosis, at least partly by reducing ABCB1 expression; ABCB1 overexpression rescues cisplatin resistance. |
| Confidence score: |
0.6778 |