| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Knockdown of circHIPK3 alleviates myocardial tissue damage, improves cardiac function, promotes proliferation and inhibits apoptosis, oxidative stress, and inflammation in LPS-induced myocarditis models. |
| Molecular mechanism: |
Not experimentally defined; authors speculate circHIPK3 may act by sponging target miRNAs. |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); inflammation (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; TUNEL; ELISA; Western Blot; IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model |
| Clinical significance: |
circHIPK3 can be used for new diagnostic and treatment strategies for myocarditis. |
| Description: |
circHIPK3 is up-regulated in LPS-induced myocarditis models (mouse myocardium and H9C2 cells). circHIPK3 knockdown improves cardiac function and reduces myocardial injury by inhibiting cardiomyocyte apoptosis, oxidative stress, and inflammation, while partially restoring cell proliferation. |
| Confidence score: |
0.5445 |