circRNA basic information
circBase ID: -
Name: hsa_circ_EIF4G3
Synonym: hsa_circ_100084
Host Gene: EIF4G3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent normal tissues
Cell lines:

HepG2; Hep3B; MHCC97H; LX2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2
Associated microRNA: hsa-miR-23a-5p
Biological function: Promotes proliferation, migration and invasion of liver cancer cells.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for hsa-miR-23a-5p to upregulate IGF2.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Clinical Sample Validation
Clinical significance:

-
Description:

In hepatocellular carcinoma, hsa_circRNA_100084 (circEIF4G3) is upregulated and promotes liver cancer cell proliferation, migration and invasion. Mechanistically, it functions as a ceRNA by sponging hsa-miR-23a-5p to increase IGF2 expression.
Confidence score:

0.6676
Other information
Title:

Circular RNA Circ100084 functions as sponge of miR‑23a‑5p to regulate IGF2 expression in hepatocellular carcinoma.

Journal: Molecular medicine reports
Published: 2020
PubMed ID: 32323783
Study type:

combined biological and clinical study
Data availability: GSE97332
Code availability: -