| Expression pattern: |
DN |
| Associated gene: |
PTEN |
| Associated microRNA: |
miR-92a-3p |
| Biological function: |
Potentially affects AML process and PTEN expression through sponging miR-92a-3p; evaluated as a diagnostic/prognostic biomarker. |
| Molecular mechanism: |
Predicted ceRNA mechanism: circ_0002232 sponges miR-92a-3p, thereby potentially regulating PTEN. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0002232 expression could distinguish AML patients from controls (ROC AUC 0.851); low circ_0002232 group had longer overall survival in whole AML and non-APL AML. |
| Description: |
circ_0002232 (a PTEN-derived circRNA) is down-regulated in AML bone marrow samples and shows diagnostic value for distinguishing AML patients from controls. The study proposes a potential ceRNA axis where circ_0002232 may sponge miR-92a-3p to influence PTEN expression, and circ_0002232 level is associated with overall survival in AML. |
| Confidence score: |
0.5121 |