| Expression pattern: |
DN |
| Associated gene: |
HOXC11 |
| Associated microRNA: |
miR-1197 |
| Biological function: |
Suppresses proliferation, migration and invasion; promotes apoptosis in prostate cancer cells. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) by sponging miR-1197, thereby modulating HOXC11. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; FISH / smFISH; Western Blot; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR |
| Clinical significance: |
- |
| Description: |
hsa_circ_0075542 is down-regulated in prostate cancer tissues and acts as a tumor suppressor in LNCaP and PC3 cells. It promotes apoptosis and inhibits proliferation/migration/invasion by sponging miR-1197 and relieving miR-1197-mediated repression of HOXC11. |
| Confidence score: |
0.8111 |