circRNA basic information
circBase ID: -
Name: hsa_circ_BCL2L12
Synonym: circ-BCL2L12-1
Host Gene: BCL2L12
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

malignant colorectal tumors; paired non-cancerous colonic fresh frozen tissue specimens
Cell lines:

Caco-2; HCT 116; HT-29; COLO 205; SW 620; DLD-1; RKO
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: CUGBP Elav-like family member 1 (CELF1), Muscleblind-like splicing regulator 1 (MBNL1), Sterile alpha motif domain-containing 4A (SAMD4A), Serine and arginine-rich splicing factor 1 (SRSF1), Serine and arginine-rich splicing factor 2 (SRSF2), Serine and arginine-rich splicing factor 3 (SRSF3), Serine and arginine-rich splicing factor 5 (SRSF5), Polypyrimidine tract binding protein 1 (PTBP1), Heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), IGF2BP1, PRDX3, HDAC2, DAPK1, EAF1
Associated microRNA: miR-1915-5p, miR-6721-5p, miR-6822-3p, miR-6510-5p, miR-1237-3p, miR-6815-3p, miR-6849-3p
Biological function: Associated with poorer overall survival when highly expressed in colorectal cancer; proposed to sponge miRNAs and bind RBPs (predicted).
Molecular mechanism: Predicted miRNA sponging (e.g., miR-1915-5p) and predicted binding to RNA-binding proteins/splicing factors (e.g., SRSF family, PTBP1, MBNL1).
Biological pathway or process:

ceRNA regulation (other); Wnt/beta-catenin (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis
Clinical significance:

circ-BCL2L12-1 overexpression is associated with shorter overall survival in CRC, particularly among TNM stage II patients.
Description:

circ-BCL2L12-1 is a newly identified BCL2L12-derived circRNA in colorectal cancer. High circ-BCL2L12-1 levels are associated with shorter overall survival, and it is predicted to function through miRNA sponging (e.g., miR-1915-5p) and binding of splicing-related RBPs.
Confidence score:

0.6548
Other information
Title:

Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer.

Journal: International journal of molecular sciences
Published: 2020
PubMed ID: 33238574
Study type:

combined biological and clinical study
Data availability: Supplementary Materials, Data Set 1
Code availability: -