circRNA basic information
circBase ID: hsa_circ_0058357
Name: hsa_circ_ATG9A
Synonym: circ_0058357
Host Gene: ATG9A
Genomic location(hg19): chr2:220086993-220090294:-
Genomic location(hg38): chr2:219222271-219225572:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human NSCLC tissues; paired-paracancerous tissues; tumor tissues
Cell lines:

HBE; H292; A549; H1299; H460
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: AVL9
Associated microRNA: miR-24-3p
Biological function: promotes proliferation and migration and tumor growth; inhibits apoptosis in NSCLC cells
Molecular mechanism: ceRNA/miRNA sponge mechanism: hsa_circ_0058357 sponges miR-24-3p to derepress AVL9
Biological pathway or process:

proliferation (promotes); migration (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

may serve as a potential target for diagnosis and gene therapy for NSCLC
Description:

hsa_circ_0058357 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration, and xenograft tumor growth while inhibiting apoptosis. It functions as a ceRNA by sponging miR-24-3p, thereby relieving miR-24-3p-mediated repression of AVL9 and driving NSCLC progression.
Confidence score:

0.6917
Other information
Title:

hsa_circ_0058357 acts as a ceRNA to promote non‑small cell lung cancer progression via the hsa‑miR‑24‑3p/AVL9 axis.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 33880595
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this published article.
Code availability: -