| Expression pattern: |
DN |
| Associated gene: |
GCNT4 |
| Associated microRNA: |
miR-1229-3p |
| Biological function: |
Circ_0005758 acts as a tumor suppressor in gastric cancer; its re-expression induces apoptosis and suppresses proliferation, migration, invasion, angiogenesis, and xenograft tumor growth. |
| Molecular mechanism: |
Circ_0005758 functions through a ceRNA mechanism by sponging miR-1229-3p to release GCNT4 expression, forming the circ_0005758/miR-1229-3p/GCNT4 feedback loop. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; EdU Staining; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Higher circ_0005758 expression was correlated with larger tumor size, advanced TNM stages and lymph node metastasis; the authors suggest circ_0005758 may be a therapeutic target for GC. |
| Description: |
Circ_0005758 is down-regulated in gastric cancer tissues and cells and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion, angiogenesis, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0005758 sponges miR-1229-3p to increase GCNT4 expression, forming a circ_0005758/miR-1229-3p/GCNT4 ceRNA axis. |
| Confidence score: |
0.7552 |