| Expression pattern: |
UP |
| Associated gene: |
METTL3, YTHDF2, CXCL1 |
| Associated microRNA: |
- |
| Biological function: |
enhances radioresistance; decreases irradiation-induced apoptosis; promotes cell survival after irradiation |
| Molecular mechanism: |
m6A-dependent regulation: METTL3 and YTHDF2 promote circRNF13 degradation; circRNF13 increases CXCL1 mRNA stability to enhance radioresistance |
| Biological pathway or process: |
m6A modification (other); mRNA stability (promotes); radioresistance (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; MeRIP / MeRIP-seq; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNase R Treatment; Sanger Sequencing; divergent primers PCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Actinomycin D / DRB Stability Assay; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
CircRNF13 was poorly expressed in CC patients that were sensitive to concurrent radiochemotherapy. |
| Description: |
circRNF13 (hsa_circ_0001346), derived from RNF13, is up-regulated in radioresistant cervical cancer tissues/cells and promotes radioresistance. Mechanistically, it increases CXCL1 mRNA stability, while its own abundance is regulated by METTL3/YTHDF2-mediated m6A modification and degradation. |
| Confidence score: |
0.8564 |