| Expression pattern: |
UP |
| Associated gene: |
AGR2, HIF-1alpha |
| Associated microRNA: |
miR-29a-3p |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
acts as a ceRNA/miRNA sponge for miR-29a-3p to derepress AGR2, thereby increasing HIF-1alpha expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); HIF-1 signaling (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
overexpressed circPVT1 was greatly correlated with positive lymph node examination and tumor size |
| Description: |
circPVT1 is upregulated in breast cancer tissues/cells and promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponge for miR-29a-3p, thereby increasing AGR2 and HIF-1alpha expression via the miR-29a-3p/AGR2/HIF-1alpha axis. |
| Confidence score: |
0.7416 |