circRNA basic information
circBase ID: -
Name: hsa_circ_LRBA
Synonym: circLRBA
Host Gene: LRBA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: gliomas
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

brain tissue; glioma tissue; GBM tumor tissue; healthy brain tissue
Cell lines:

HEK293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: SRRM4
Associated microRNA: -
Biological function: unknown
Molecular mechanism: SRRM4 overexpression induces circLRBA biogenesis in HEK293 cells.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; Bioinformatics Analysis; RNase R Treatment; divergent primers PCR; Transfection; RT-PCR
Clinical significance:

-
Description:

circLRBA is an SRRM4-driven circRNA whose presence in HEK293 cells depends on SRRM4 overexpression, indicating SRRM4 can promote its biogenesis. The study does not report a specific disease-associated expression change or downstream functional mechanism for circLRBA in gliomas/GBM.
Confidence score:

0.5598
Other information
Title:

SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion.

Journal: Cells
Published: 2020
PubMed ID: 33207694
Study type:

combined biological and clinical study
Data availability: GSE148813; GSE159260
Code availability: -