| Expression pattern: |
UP |
| Associated gene: |
LHX2, Ago2 |
| Associated microRNA: |
miR-1238 |
| Biological function: |
Promotes PCa cell proliferation and tumor growth, facilitates cell-cycle progression and inhibits apoptosis; promotes migration and invasion via EMT. |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-1238, thereby upregulating LHX2 expression (circFMN2/miR-1238/LHX2 axis). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High expression of circFMN2 in PCa tissues was significantly correlated with advanced tumor stage, lymph node metastasis, and distant metastasis; circFMN2 was detectable in serum exosomes from PCa patients, suggesting biomarker potential. |
| Description: |
circFMN2 (hsa_circ_0005100), derived from FMN2, is up-regulated in prostate cancer tissues and cell lines and shows oncogenic effects. It promotes proliferation, migration/invasion and EMT and inhibits apoptosis, partly via a ceRNA mechanism that sponges miR-1238 to upregulate LHX2; it is also detectable in serum exosomes from PCa patients. |
| Confidence score: |
0.8512 |