circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues
Cell lines:

MCF-10A; BT474; MCF-7; T47D; BT474/OX; MCF-7/OX; T47D/OX
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SKA1, MRP1, MDR1, LRP1, Notch2, GSK-3beta, beta-catenin
Associated microRNA: miR-525-5p
Biological function: Promotes oxaliplatin resistance (increases IC50) and enhances migration and invasion while inhibiting apoptosis in OX-resistant breast cancer cells.
Molecular mechanism: circFAT1 sponges miR-525-5p to upregulate SKA1, which activates Notch and Wnt signaling pathways to drive oxaliplatin resistance.
Biological pathway or process:

Notch (promotes); Wnt/beta-catenin (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); chemoresistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis
Clinical significance:

Higher circFAT1 expression is associated with oxaliplatin-resistant breast cancer tissues, suggesting a potential therapeutic target in OX-resistant BC.
Description:

circFAT1 is upregulated in oxaliplatin-resistant breast cancer tissues/cells and promotes oxaliplatin resistance, migration, and invasion while suppressing apoptosis. Mechanistically, it targets (sponges) miR-525-5p to increase SKA1, which in turn activates Notch and Wnt signaling.
Confidence score:

0.5607
Other information
Title:

Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway.

Journal: Bioengineered
Published: 2021
PubMed ID: 34288822
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -