| Expression pattern: |
UP |
| Associated gene: |
MIEN1 |
| Associated microRNA: |
miR-136 |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, invasion and metastasis; knockdown of circRNA_100876 suppresses proliferation, migration and invasion in AGS and SGC7901 cells. |
| Molecular mechanism: |
circRNA_100876 functions as a ceRNA by sponging miR-136, thereby relieving miR-136-mediated inhibition of MIEN1 and upregulating MIEN1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential new biomarker for gastric cancer progression. |
| Description: |
circRNA_100876 is up-regulated in gastric cancer tissues and acts as an oncogenic circRNA. Functionally, it promotes GC cell proliferation, migration, invasion and metastasis. Mechanistically, circRNA_100876 sponges miR-136 to upregulate MIEN1 expression, forming a circRNA_100876/miR-136/MIEN1 regulatory axis. |
| Confidence score: |
0.6479 |