circRNA basic information
circBase ID: hsa_circ_0043469
Name: hsa_circ_ERBB2
Synonym: circ-CCAC1
Host Gene: ERBB2
Genomic location(hg19): chr17:37880978-37882106:+
Genomic location(hg38): chr17:39724725-39725853:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006639
MONDO name: adrenal cortex carcinoma
Disease details: Adrenocortical carcinoma
Disease DO ID:
 3948, 3959, 660
Disease MeSH ID:
 -
Disease NCIt ID:
 C9325
Disease ICD11 ID:
 114092945
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ACC tissues; noncancerous tissues
Cell lines:

H295R; SW-13; Y1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: C22orf46
Associated microRNA: miR-514a-5p
Biological function: Promotes ACC cell proliferation, migration, and invasion; suppresses apoptosis
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-514a-5p to upregulate C22orf46
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot
Clinical significance:

High circ-CCAC1 expression was linked to worse overall survival for ACC patients after surgery
Description:

circ-CCAC1 is up-regulated in ACC tissues and cell lines and is associated with worse overall survival. Functionally, circ-CCAC1 promotes ACC cell proliferation, migration, and invasion and inhibits apoptosis by acting as a ceRNA that sponges miR-514a-5p to upregulate C22orf46.
Confidence score:

0.8025
Other information
Title:

Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis.

Journal: BioMed research international
Published: 2020
PubMed ID: 33195693
Study type:

combined biological and clinical study
Data availability: The datasets used in the study are available from the corresponding author.
Code availability: -