| Expression pattern: |
UP |
| Associated gene: |
PLA2G6, Ago2 |
| Associated microRNA: |
miR-663a |
| Biological function: |
promotes BPD progression by enhancing apoptosis and inhibiting proliferation |
| Molecular mechanism: |
ceRNA mechanism: circABCC4 sponges miR-663a to increase PLA2G6 expression |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining; TUNEL; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
circABCC4 expression was increased in peripheral blood of BPD patients and was positively correlated with poor long-term prognosis; potential diagnostic/prognostic biomarker |
| Description: |
circABCC4 is up-regulated in BPD (patient peripheral blood and hyperoxia models) and mainly localizes to the cytoplasm. It promotes BPD progression by acting as a ceRNA that sponges miR-663a, relieving repression of PLA2G6, thereby enhancing apoptosis and inhibiting proliferation. |
| Confidence score: |
0.8289 |