| Expression pattern: |
UP |
| Associated gene: |
ZEB2 |
| Associated microRNA: |
hsa-miR-145-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-199a-3p |
| Biological function: |
Promotes ccRCC cell proliferation, migration, and invasion; may promote tumor growth and metastasis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-145-5p, relieving repression on ZEB2 (predicted/partially supported). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0005875 expression was associated with tumor size, pathological TNM stage, histological differentiation, and lymphatic metastasis; proposed as a potential biomarker of ccRCC. |
| Description: |
In ccRCC, hsa_circ_0005875 is up-regulated in tumor tissues and most renal carcinoma cell lines. Its overexpression promotes proliferation, migration, and invasion, and it may function as a miR-145-5p sponge to modulate the miR-145-5p/ZEB2 axis, suggesting potential biomarker value. |
| Confidence score: |
0.7291 |