circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_103809
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent tissues; tumors
Cell lines:

sum-1315; MCF7; MDA-MB-231; MCF10A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: AKT, p-AKT, BCL2, Bax
Associated microRNA: -
Biological function: promotes proliferation, represses apoptosis, and accelerates cell cycle progression; promotes tumor formation in vivo
Molecular mechanism: regulates PI3K/AKT signaling; affects phosphorylation of AKT and apoptosis-related proteins (BCL2, Bax)
Biological pathway or process:

PI3K/AKT (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

circ_103809 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer cell proliferation, accelerates cell-cycle progression, inhibits apoptosis, and enhances tumor formation in vivo, at least partly by activating the PI3K/AKT signaling pathway (increased p-AKT and BCL2, decreased Bax upon knockdown reversal).
Confidence score:

0.5442
Other information
Title:

circ_103809 promotes breast cancer progression by regulating the PI3K/AKT signaling pathway.

Journal: Oncology letters
Published: 2020
PubMed ID: 32382325
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this published article.
Code availability: -