| Expression pattern: |
UP |
| Associated gene: |
ENDOPDI |
| Associated microRNA: |
miR-299-3p |
| Biological function: |
Promotes cisplatin resistance and gastric cancer progression (cell viability/proliferation, migration, invasion) and inhibits apoptosis; circ_0110805 knockdown enhances cisplatin sensitivity and suppresses tumor growth. |
| Molecular mechanism: |
ceRNA mechanism: circ_0110805 sponges miR-299-3p to upregulate ENDOPDI, affecting cisplatin sensitivity and malignant phenotypes. |
| Biological pathway or process: |
ceRNA regulation (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0110805 is up-regulated in cisplatin-resistant gastric cancer tissues and cells. Its knockdown increases cisplatin sensitivity and suppresses malignant behaviors by sponging miR-299-3p to reduce ENDOPDI expression, including in a xenograft model. |
| Confidence score: |
0.6536 |