| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-217 |
| Biological function: |
promotes proliferation, migration and invasion of NSCLC cells |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-217 to upregulate ZEB1 (ceRNA axis). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
High hsa_circ_0023404 expression predicted short overall survival in NSCLC. |
| Description: |
hsa_circ_0023404 is upregulated in NSCLC tissues/cell lines and promotes NSCLC cell proliferation, migration and invasion. Mechanistically, it sponges miR-217 to upregulate ZEB1, influencing EMT-associated markers. High hsa_circ_0023404 expression is associated with shorter overall survival in NSCLC patients. |
| Confidence score: |
0.7618 |