circRNA basic information
circBase ID: hsa_circ_0023404
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr11:71668272-71671937:+
Genomic location(hg38): chr11:71957226-71960891:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; paired adjacent nontumorous tissues
Cell lines:

HBE; A549; H322; H1299; GLC-82; SPC-A1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: miR-217
Biological function: promotes proliferation, migration and invasion of NSCLC cells
Molecular mechanism: Acts as a miRNA sponge for miR-217 to upregulate ZEB1 (ceRNA axis).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot
Clinical significance:

High hsa_circ_0023404 expression predicted short overall survival in NSCLC.
Description:

hsa_circ_0023404 is upregulated in NSCLC tissues/cell lines and promotes NSCLC cell proliferation, migration and invasion. Mechanistically, it sponges miR-217 to upregulate ZEB1, influencing EMT-associated markers. High hsa_circ_0023404 expression is associated with shorter overall survival in NSCLC patients.
Confidence score:

0.7618
Other information
Title:

Circular RNA hsa_circ_0023404 promotes proliferation, migration and invasion in non-small cell lung cancer by regulating miR-217/ZEB1 axis.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 31496723
Study type:

combined biological and clinical study
Data availability: -
Code availability: -