| Expression pattern: |
DN |
| Associated gene: |
IFITM1 |
| Associated microRNA: |
Hsa-miR-432-5p, Hsa-miR-138-5p, Hsa-miR-1264, Hsa-miR-658, Hsa-miR-873-5p |
| Biological function: |
potential regulator of migraine pathology; may modulate migraine pathogenesis via inflammatory factors |
| Molecular mechanism: |
Predicted ceRNA network (circRNA-miRNA-mRNA); literature-noted ceRNA regulation (IFITM1) mentioned. |
| Biological pathway or process: |
PI3K/AKT (other); inflammation (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May offer value as a regulator of migraine pathology (potential biomarker/regulator suggested). |
| Description: |
hsa_circRNA_102413 (hsa_circ_0003745) is down-regulated in migraine patient plasma and validated by qRT-PCR. It was included in GO/KEGG and ceRNA-network predictions and highlighted as a potential regulator of migraine pathology, with hypothesized links to PI3K/AKT-associated inflammatory processes (without direct mechanistic validation). |
| Confidence score: |
0.5135 |