circRNA basic information
circBase ID: hsa_circ_0003745
Name: hsa_circ_PIP5K1C
Synonym: hsa_circRNA_102413
Host Gene: PIP5K1C
Genomic location(hg19): chr19:3656402-3661999:-
Genomic location(hg38): chr19:3656404-3662001:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005277
MONDO name: migraine disorder
Disease details: Migraine
Disease DO ID:
6364
Disease MeSH ID:
D008881
Disease NCIt ID:
C89715
Disease ICD11 ID:
669367341
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; peripheral blood

Cell lines:

-

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DN
Associated gene: IFITM1
Associated microRNA: Hsa-miR-432-5p, Hsa-miR-138-5p, Hsa-miR-1264, Hsa-miR-658, Hsa-miR-873-5p
Biological function: potential regulator of migraine pathology; may modulate migraine pathogenesis via inflammatory factors
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA); literature-noted ceRNA regulation (IFITM1) mentioned.
Biological pathway or process:

PI3K/AKT (other); inflammation (other); ceRNA regulation (other)

Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis

Clinical significance:

May offer value as a regulator of migraine pathology (potential biomarker/regulator suggested).

Description:

hsa_circRNA_102413 (hsa_circ_0003745) is down-regulated in migraine patient plasma and validated by qRT-PCR. It was included in GO/KEGG and ceRNA-network predictions and highlighted as a potential regulator of migraine pathology, with hypothesized links to PI3K/AKT-associated inflammatory processes (without direct mechanistic validation).

Confidence score:

0.5135

Other information
Title:

Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.

Journal: BioMed research international
Published: 2020
PubMed ID: 33178826
Study type:

combined biological and clinical study

Data availability: All data generated or analyzed during this study are included in this article.
Code availability: -