| Expression pattern: |
DN |
| Associated gene: |
TGIF1, IFITM1, PRKRIR |
| Associated microRNA: |
Hsa-miR-331-3p, Hsa-miR-4646-5p, Hsa-miR-4797-5p, Hsa-miR-3919, Hsa-miR-3190-3p |
| Biological function: |
potential regulator of migraine pathology; may influence inflammation-related factors |
| Molecular mechanism: |
Predicted ceRNA network (circRNA-miRNA-mRNA); literature-noted ceRNA regulation of TGIF1/IFITM1/PRKRIR is mentioned. |
| Biological pathway or process: |
PI3K/AKT (other); inflammation (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May offer value as a regulator of migraine pathology (potential biomarker/regulator suggested). |
| Description: |
hsa_circRNA_000367 (hsa_circ_0000367) is down-regulated in migraine patient plasma and validated by qRT-PCR. It was used for GO/KEGG and ceRNA-network predictions, with suggested links to PI3K/AKT-related inflammatory mechanisms, and is highlighted as a potential regulator of migraine pathology. |
| Confidence score: |
0.5135 |