| Expression pattern: |
UP |
| Associated gene: |
XBP1 |
| Associated microRNA: |
miR-324-5p |
| Biological function: |
Circ_0079593 promotes glioma cell proliferation, migration, invasion, angiogenesis, glycolysis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0079593 functions as a miR-324-5p sponge to up-regulate downstream XBP1, thereby facilitating glioma progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); glycolysis (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0079593 might be a promising therapeutic target for glioma |
| Description: |
circ_0079593 is up-regulated in glioma tissues and cell lines and is mainly cytoplasmic. It promotes glioma proliferation, migration, invasion, angiogenesis, glycolysis and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_0079593 acts as a ceRNA for miR-324-5p to increase XBP1 expression, forming the circ_0079593/miR-324-5p/XBP1 axis and suggesting therapeutic potential in glioma. |
| Confidence score: |
0.8175 |