| Expression pattern: |
UP |
| Associated gene: |
QKI, EGFR, BCL2L1, PTPN11 |
| Associated microRNA: |
miR-1236-3p, miR-129-5p, miR-141-5p, miR-205-5p, miR-29a-5p, miR-942-5p |
| Biological function: |
Potential noninvasive diagnostic biomarker for breast cancer; expression was positively correlated with Ki-67 level; may participate in a circRNA-miRNA-mRNA regulatory network involved in cancer development and progression. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network based on miRanda, MirTarget, STRING, Cytoscape and KEGG pathway analysis. |
| Biological pathway or process: |
ceRNA regulation (other); autophagy (other); NF-kappaB (other); JAK/STAT (other); proliferation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0001640 had diagnostic potential for breast cancer, with AUC 0.7161 in the discovery cohort, 0.9802 in the validation cohort and 0.8860 in the combined cohort; its expression was positively correlated with Ki-67 level. |
| Description: |
circ_0001640 was significantly up-regulated in whole blood from breast cancer patients and showed diagnostic value in ROC analyses. Its expression correlated positively with Ki-67 level and varied among breast cancer subtypes, with highest expression in HER2+ cancer and lowest in triple-negative cancer. The study suggests circ_0001640 may act through a predicted circRNA-miRNA-mRNA network, but mechanistic functions were not experimentally validated. |
| Confidence score: |
0.459 |