| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-4644, hsa-miR-623 |
| Biological function: |
acts as a diagnostic serum biomarker for NSCLC; associated with histological type, TNM stage, lymph node metastasis, distal metastasis, postoperative dynamic monitoring, and poor prognosis |
| Molecular mechanism: |
predicted post-transcriptional ceRNA mechanism through hsa_circ_0023179-miRNA-mRNA regulatory network |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; circRNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0023179 may serve as a serum marker for NSCLC diagnosis and prediction; combined diagnosis with CEA, SCC, and Cyfra21-1 improves diagnostic value; postoperative decrease suggests dynamic monitoring potential; high expression is linked to poor prognosis |
| Description: |
hsa_circ_0023179 is a human LRP5-derived circRNA that is up-regulated in NSCLC tissues, serum, and cell lines. The study supports its use as a circulating diagnostic biomarker with better diagnostic performance than conventional serum markers and shows association with advanced clinicopathological features, postoperative monitoring potential, and poor prognosis. Mechanistically, it is mainly cytoplasmic and was predicted to participate in a circRNA-miRNA-mRNA regulatory network, but its biological regulatory role remains largely unvalidated. |
| Confidence score: |
0.7417 |