| Expression pattern: |
UP |
| Associated gene: |
SRSF1 |
| Associated microRNA: |
miR-638 |
| Biological function: |
Circ-PABPN1 acts as a tumor-promoting functional effector in CRC: it supports cell viability, colony formation, invasion, migration and tumor growth, suppresses apoptosis, and its down-regulation contributes to propofol-mediated anti-CRC effects. |
| Molecular mechanism: |
Propofol down-regulates circ-PABPN1; reduced circ-PABPN1 increases miR-638, which decreases SRSF1 expression, thereby repressing CRC growth and metastasis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Circ-PABPN1 was overexpressed in CRC clinical tumor tissues compared with matched normal tissues, suggesting involvement in CRC development; no diagnostic or prognostic performance was reported. |
| Description: |
Circ-PABPN1 is up-regulated in CRC tissues and cells and functions as a pro-tumor circRNA. Propofol suppresses CRC development partly by down-regulating circ-PABPN1, which releases miR-638 activity and reduces SRSF1 expression, leading to decreased growth, invasion, migration, metastasis and increased apoptosis. |
| Confidence score: |
0.7183 |