| Expression pattern: |
UP |
| Associated gene: |
YES1 |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
Promotes prostate cancer cell viability/proliferation, migration, invasion and aerobic glycolysis; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge binding miR-515-5p, thereby relieving miR-515-5p-mediated repression of YES1. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0057553 is up-regulated in prostate cancer tissues and cell lines and promotes proliferation/viability, migration, invasion and glycolysis while inhibiting apoptosis. Mechanistically, it binds (sponges) miR-515-5p to derepress YES1, and circ_0057553 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7792 |