| Expression pattern: |
DN |
| Associated gene: |
HDAC4 |
| Associated microRNA: |
miR-216a-3p |
| Biological function: |
Suppresses proliferation, migration/invasion and inflammatory response of RA-FLSs; promotes apoptosis; alleviates RA pathology in rats. |
| Molecular mechanism: |
Exosomal circFBXW7 functions as a ceRNA by sponging miR-216a-3p, thereby upregulating HDAC4; miR-216a-3p directly targets HDAC4 3ʹUTR. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); inflammation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; ELISA; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circFBXW7 is decreased in clinical RA samples (synovial tissues; serum exosomes) compared with healthy controls, suggesting potential therapeutic/biomarker relevance. |
| Description: |
In rheumatoid arthritis, circFBXW7 is down-regulated in patient synovial tissues and serum exosomes. MSC-derived exosomal circFBXW7 suppresses RA-FLS proliferation, migration/invasion and inflammatory cytokine production and alleviates RA injury in rats by sponging miR-216a-3p to restore HDAC4 expression. |
| Confidence score: |
0.8327 |