| Expression pattern: |
DN |
| Associated gene: |
NME2 |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
inhibits invasion and migration (metastasis-related behaviors) of NSCLC cells |
| Molecular mechanism: |
circPSMC3 sponges miR-182-5p to upregulate NME2 (ceRNA mechanism) |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Pearson correlation analysis; Transfection; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Lower circPSMC3 expression was closely associated with lymph node metastasis and higher TNM stage in NSCLC patients. |
| Description: |
CircPSMC3 is down-regulated in NSCLC tissues and its low expression is associated with lymph node metastasis and higher TNM stage. Functionally, circPSMC3 suppresses NSCLC cell migration and invasion by sponging miR-182-5p, thereby upregulating NME2. |
| Confidence score: |
0.686 |