circRNA basic information
circBase ID: -
Name: hsa_circ_DOCK1
Synonym: hsa_circ_100721
Host Gene: DOCK1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral cavity squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

oral carcinoma tissues; adjacent normal tissues / para-carcinoma tissue
Cell lines:

CAL-27; SCC-9; SCC-25; HOK
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: BIRC3
Associated microRNA: miR-196a-5p
Biological function: suppresses apoptosis (anti-apoptosis) in OSCC cells
Molecular mechanism: Functions as a competing endogenous RNA (ceRNA) to sponge miR-196a-5p, thereby regulating BIRC3 expression and apoptosis.
Biological pathway or process:

apoptosis (inhibits); ceRNA regulation (other); p53 signaling (other)
Detected method:
Q
S
M
Validation methods:

RT-qPCR; Microarray; circRNA-seq; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

circDOCK1 could represent a novel potential biomarker and therapeutic target of OSCC.
Description:

circDOCK1 is up-regulated in OSCC tissues and cell lines and acts as an anti-apoptotic circRNA. It functions as a ceRNA to sponge miR-196a-5p, thereby increasing BIRC3 expression and suppressing OSCC cell apoptosis, suggesting biomarker/therapeutic potential.
Confidence score:

0.7399
Other information
Title:

CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC.

Journal: Oncology reports
Published: 2018
PubMed ID: 29286141
Study type:

combined biological and clinical study
Data availability: -
Code availability: -