| Expression pattern: |
UP |
| Associated gene: |
HOXA9, Wnt/beta-catenin signaling, beta-catenin, c-Myc, Cyclin D1 |
| Associated microRNA: |
miR-638 |
| Biological function: |
promotes proliferation, migration, invasion, and tumorigenesis in GBM |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-638 to upregulate HOXA9 and activate Wnt/beta-catenin signaling |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); tumorigenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0043278 may function as a new biomarker and a potential target for the diagnosis and therapy of GBM |
| Description: |
circ_0043278 is up-regulated in GBM tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion and in vivo tumor growth). Mechanistically, it acts as a ceRNA that sponges miR-638, leading to increased HOXA9 and activation of Wnt/beta-catenin signaling. |
| Confidence score: |
0.6478 |