| Expression pattern: |
DN |
| Associated gene: |
MAPK14, EIF4AIII |
| Associated microRNA: |
miR-421 |
| Biological function: |
May inhibit tumorigenesis of HCC (tumor suppressor role) via miRNA sponging; proposed interaction with EIF4AIII may relate to its downregulation. |
| Molecular mechanism: |
Proposed ceRNA mechanism: hsa_circ_0064286 sponges miR-421 to relieve miR-421-mediated suppression of MAPK14; potential binding by RBP EIF4AIII. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (other); cell cycle (other); proliferation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Potential diagnostic biomarker for HCC in serum; ROC AUC 0.971 with sensitivity 88.3% and specificity 96%. |
| Description: |
In serum from Egyptian HCC patients, hsa_circ_0064286 is significantly down-regulated and shows strong diagnostic performance by ROC analysis. Mechanistically, the paper proposes a ceRNA axis in which hsa_circ_0064286 sponges miR-421 to affect MAPK14, and also suggests potential interaction with the RBP EIF4AIII. |
| Confidence score: |
0.4187 |