circRNA basic information
circBase ID: hsa_circ_0032462
Name: -
Synonym: circ_0032462
Host Gene: -
Genomic location(hg19): chr14:72054287-72090953:+
Genomic location(hg38): chr14:71587570-71624236:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

143B; MG-63; U2OS; SOSP-9607; SJSA-1; HOS; hFOB1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KIF3B
Associated microRNA: -
Biological function: Promotes osteosarcoma cell proliferation, migration, and invasion; enhances osteosarcoma cell progression.
Molecular mechanism: Upregulates KIF3B mRNA and protein expression; KIF3B mediates circ_0032462-induced oncogenic effects.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

hsa_circ_0032462/KIF3B can serve as a novel biomarker and chemotherapeutic target for OS.
Description:

circ_0032462 (hsa_circ_0032462) is up-regulated in osteosarcoma cell lines and promotes proliferation, migration, and invasion. It enhances KIF3B mRNA/protein expression, and KIF3B is required for circ_0032462-driven oncogenic phenotypes.
Confidence score:

0.528
Other information
Title:

Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.

Journal: Technology in cancer research & treatment
Published: 2020
PubMed ID: 33153390
Study type:

biological research
Data availability: GSE96964; GSE36001; GSE33382; GSE42352
Code availability: -