| Expression pattern: |
UP |
| Associated gene: |
EIF5A2 |
| Associated microRNA: |
miR-218-5p |
| Biological function: |
promotes doxorubicin resistance, viability, migration, invasion and EMT in HCC cells; circ_0003998 knockdown sensitizes HCC cells to DOX and enhances DOX cytotoxicity in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0003998 sponges miR-218-5p to regulate EIF5A2 expression, thereby promoting DOX resistance |
| Biological pathway or process: |
chemoresistance (promotes); EMT (promotes); migration (promotes); invasion (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
high circ_0003998 expression is associated with DOX resistance and may indicate poor response to DOX |
| Description: |
circ_0003998 is up-regulated in HCC, particularly in DOX-resistant tissues/cells, and promotes DOX resistance along with migration, invasion and EMT. Mechanistically, it acts as a ceRNA that sponges miR-218-5p to increase EIF5A2 expression, and its knockdown sensitizes HCC cells to DOX in vitro and in xenograft models. |
| Confidence score: |
0.7177 |