circRNA basic information
circBase ID: hsa_circ_0007813
Name: hsa_circ_DHTKD1
Synonym: -
Host Gene: DHTKD1
Genomic location(hg19): chr10:12123470-12162266:+
Genomic location(hg38): chr10:12081471-12120267:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissues; paired adjacent normal tissues; normal bladder epithelium tissues
Cell lines:

RT4; UM-UC-3; T24; 5637; J82; SV-HUC-1; HEK-293
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2R
Associated microRNA: hsa-miR-361-3p
Biological function: Promotes bladder cancer cell proliferation, migration, invasiveness, tumor growth and metastasis; promotes autophagy.
Molecular mechanism: Acts as a ceRNA by sponging hsa-miR-361-3p to regulate IGF2R expression, affecting autophagy and tumor progression.
Biological pathway or process:

autophagy (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; FISH / smFISH; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence)
Clinical significance:

High hsa_circ_0007813 expression was associated with larger tumor size, higher primary tumor T stage, higher pathologic grade, and poorer prognosis.
Description:

hsa_circ_0007813 is up-regulated in bladder cancer and predicts worse overall survival. It promotes proliferation, migration/invasion, tumor growth and metastasis, and regulates autophagy by sponging hsa-miR-361-3p to increase IGF2R expression.
Confidence score:

0.831
Other information
Title:

Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation.

Journal: Cell death & disease
Published: 2021
PubMed ID: 34365465
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -