| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
prognostic biomarker for lower risk of progression |
| Molecular mechanism: |
Not specified (no SCEs or conserved miRNA binding sites reported for circCDYL in this study). |
| Biological pathway or process: |
not specified |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Nuclear-Cytoplasmic Fractionation; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High circCDYL expression is associated with a significantly lower risk of progression in NMIBC (independent of the linear transcript and host gene). |
| Description: |
circCDYL is upregulated in the less aggressive NMIBC risk class and higher expression predicts a lower risk of progression independently of the linear transcript and host gene. It is mainly localized in the cytoplasm (detected in FL3 and T24 fractions), and the study reports no enrichment of SCEs or conserved miRNA binding sites for circCDYL. |
| Confidence score: |
0.4679 |