circRNA basic information
circBase ID: hsa_circ_0001013
Name: hsa_circ_KIAA1841
Synonym: -
Host Gene: KIAA1841
Genomic location(hg19): chr2:61339656-61345251:+
Genomic location(hg38): chr2:61112521-61118116:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; plasma
Cell lines:

SGC-7901; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CSNK2A2, TP53, TRIM68, ATF4, MTDH, PPP2R2A, RASAL2, IL6, CDKN1A, FOXO3, FOXO1, RARG, MITF, ADCY6, CLOCK, TSC22D3, FGF9, NTM, CYLD, BCL2, CCND2, PDCD4, RECK, FLOT1, PTEN, GSK38, ZFAND4, BDNF, SATB2, CHL1, CADM1, TP53INP1, TCEAL7, FBXW7, LRRC4, ULBP2, PDK4, TRIM8, TIAM1, UQCRFS1, TUSC2, NSUN5, CD82, BMF, PMAIP1, MTHFD1, FOXJ2, MAPK1, MUC1, ITGA5, PDE4B, RAP1A, STAT3, CSNK2A1, MZF1, MIF, CAB39, ABCB1, MYC, RAB14, CPNE3, RAB5A, DCBLD2, IL6R, ADAM10, TSC1, CDKN2D, MAP3K1, ABCG2, SPRED2, PIK3R1, SLC39A8, PAX6, BCL2L11, SPDEF, PRDX1, GSTP1, LHCGR, ITGAV, TWIST1, CD274, CDC42, MTOR, SMAD4, CDH1, CASP3, GSK3B, CDKN1A, TP53, MCL1
Associated microRNA: hsa-miR-1197, hsa-miR-1225-3p, hsa-miR-1243, hsa-miR-1250-5p, hsa-miR-1261, hsa-miR-1294, hsa-miR-1304-5p, hsa-miR-146b-3p, hsa-miR-1827, hsa-miR-323a-3p, hsa-miR-450b-3p, hsa-miR-548g-3p, hsa-miR-548m, hsa-miR-556-3p, hsa-miR-562, hsa-miR-576-5p, hsa-miR-624-3p, hsa-miR-924, hsa-miR-1228-3p, hsa-miR-1256, hsa-miR-1283, hsa-miR-136-5p, hsa-miR-182-5p, hsa-miR-197-3p, hsa-miR-330-5p, hsa-miR-337-3p, hsa-miR-451a, hsa-miR-487a-3p, hsa-miR-488-3p, hsa-miR-510-5p, hsa-miR-513a-3p, hsa-miR-548c-3p, hsa-miR-570-3p, hsa-miR-654-3p, hsa-miR-665, hsa-miR-876-3p, hsa-miR-942-5p
Biological function: may play a key role in the pathogenesis of GC; may act as a ceRNA
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA) based on bioinformatics; core network links hsa_circ_0001013 with 10 miRNAs and 18 hub genes
Biological pathway or process:

apoptosis (other); PI3K/AKT (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection
Clinical significance:

The network may become a new molecular biomarker
Description:

hsa_circ_0001013 is up-regulated in gastric cancer tissue and plasma (microarray) and shows higher expression in SGC-7901 than GES-1 (RT-qPCR). Bioinformatics predicts it functions as a ceRNA, forming a core circRNA-miRNA-mRNA network with 10 miRNAs and hub genes enriched in apoptosis- and PI3K-Akt-related pathways, suggesting a key role in GC pathogenesis.
Confidence score:

0.3684
Other information
Title:

Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis.

Journal: World journal of surgical oncology
Published: 2022
PubMed ID: 35164778
Study type:

combined biological and clinical study
Data availability: GSE83521; GSE93541
Code availability: -