| Expression pattern: |
UP |
| Associated gene: |
SGPP1, Ago2, exosomes |
| Associated microRNA: |
miR-34a-5p |
| Biological function: |
promotes cell viability and invasion; inhibits cell apoptosis; promotes tumor growth |
| Molecular mechanism: |
Exosome-transmitted circ-HMGCS1 sponges miR-34a-5p to regulate SGPP1 expression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Exosomal circ-HMGCS1 was increased in the serums of colon cancer patients. |
| Description: |
circ-HMGCS1 is up-regulated in colon cancer (notably in serum- and cell-derived exosomes) and functions as an oncogenic circRNA. It sponges miR-34a-5p to increase SGPP1, thereby promoting proliferation/viability and invasion while inhibiting apoptosis; sevoflurane suppresses colon cancer progression partly by downregulating this exosome-transmitted circ-HMGCS1/miR-34a-5p/SGPP1 axis. |
| Confidence score: |
0.7045 |