circRNA basic information
circBase ID: hsa_circ_0000260
Name: hsa_circ_SMC3
Synonym: -
Host Gene: hsa-miR-129-5p
 
 
 
Disease basic information
DO ID:
 3717
DO name: gastric adenocarcinoma
Disease details: gastric adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HGC27, AGS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MMP11
Associated microRNA: hsa-miR-129-5p
Biological function: Circ_0000260 knockdown lessened CDDP chemoresistance, suppressed cell proliferation, migration, invasion and adhesion, and induced apoptosis.
Molecular mechanism: regulated the expression of MMP11 by targeting hsa-miR-129-5p
Survival: -
Supported No.:
 1
Description:

Circ_0000260 regulated CDDP chemoresistance of GAC by promoting MMP11 expression via targeting miR-129-5p.
Other information
Title:

Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p.

Journal: Cancer Manag Res
Published: 2020/10/31
PubMed ID: 33122949