| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
May be involved in tumor growth of NSCLC and potentially acts as an oncogene; serves as a diagnostic biomarker for early NSCLC in whole blood and tissue. |
| Molecular mechanism: |
Not specified; study mainly evaluates expression, stability, and diagnostic performance rather than downstream mechanistic targets. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Whole blood-derived circUSP10 shows good diagnostic performance for early-stage NSCLC and is associated with tumor size and TNM stage in tissue cohort. |
| Description: |
circUSP10 (hsa_circ_0003026), derived from USP10, is up-regulated in NSCLC tumor tissues and in patients’ whole blood. It is stable (RNase R resistant and longer half-life with actinomycin D) and shows strong ROC-based diagnostic performance for early-stage (TNM I) NSCLC. |
| Confidence score: |
0.6556 |