| Expression pattern: |
UP |
| Associated gene: |
DNMT3B |
| Associated microRNA: |
miR-651-5p |
| Biological function: |
Promotes CRC cell growth, migration, invasion and metastatic potential; knockdown represses these malignant characteristics. |
| Molecular mechanism: |
circ_0000467 acts as a miRNA sponge for miR-651-5p and up-regulates DNMT3B expression through the miR-651-5p/DNMT3B axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; BrdU; Transwell Assay; RIP (RNA Immunoprecipitation); Western Blot; Luciferase Reporter Assay |
| Clinical significance: |
Circ_0000467 may be a potential diagnostic biomarker and therapeutic target for CRC. |
| Description: |
circ_0000467 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC cell growth, migration and invasion by sponging miR-651-5p, thereby increasing DNMT3B expression, and may serve as a potential diagnostic biomarker and therapeutic target. |
| Confidence score: |
0.7581 |