| Expression pattern: |
UP |
| Associated gene: |
ANXA2 |
| Associated microRNA: |
miR-130a-5p |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, EMT, tumor growth and metastasis; knockdown suppresses these malignant behaviors. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-130a-5p, thereby relieving repression of ANXA2 and promoting malignant progression/EMT in HCC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
High hsa_circ_102559 expression is associated with lower overall survival and with tumor size, lymph node metastasis, and TNM stage; suggested as a potential biomarker/therapeutic target for HCC. |
| Description: |
hsa_circ_102559 is up-regulated in hepatocellular carcinoma and promotes proliferation, migration/invasion, EMT, and in vivo tumor growth/metastasis. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA sponge for miR-130a-5p, increasing ANXA2 expression. High expression is associated with worse overall survival and metastatic clinicopathologic features. |
| Confidence score: |
0.8457 |